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Hyaluronidase concerns

September 16, 2008
Dear Dr Rivkin

Can you tell me about this enzyme? Is it completely safe when used as an antidote to HA's? Does it distinguish between the synthetic HA's of eg Restylane and the natural HA's present in the body? Or can it dissolve those too? If it does affect the natural HA's, what are the consequences and will they replenish themselves?

Many thanks for your advice,

Anna


hi anna,
i have used this enzyme alot, but i use it in very small injections. i have never seen damage to the natural tissues, although i have heard of cases where it was suspected that hyaluronidase caused damage.
i inject the minimum possible and it works to just dissolve the synthetic HA. i then bring the patient back in a week to make sure that the hyaluronidase has had the desired effect.
hope that helps

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